Mass spectrometric sequencing of site-specific carcinogen-modified oligodeoxyribonucleotides containing bulky benzo[a]pyrene diol epoxide-deoxyguanosyl adducts.

Abstract

Site-specific carcinogen-modified oligonucleotides are often used in site-directed mutagenesis and other biological and biochemical studies of structure-function relationships. Postsynthetic analysis and confirmation of the sites of carcinogen binding in such oligonucleotides is an important step in the characterization of these site-specific carcinogen-DNA… (More)

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@article{Ni1998MassSS, title={Mass spectrometric sequencing of site-specific carcinogen-modified oligodeoxyribonucleotides containing bulky benzo[a]pyrene diol epoxide-deoxyguanosyl adducts.}, author={J. Ni and Tiegang Liu and Alexander Kolbanovskiy and Jacek Krzeminski and S. Amin and Nicholas E. Geacintov}, journal={Analytical biochemistry}, year={1998}, volume={264 2}, pages={222-9} }