Mass spectrometric identification of modified urinary nucleosides used as potential biomedical markers by LC-ITMS coupling.

@article{Kammerer2005MassSI,
  title={Mass spectrometric identification of modified urinary nucleosides used as potential biomedical markers by LC-ITMS coupling.},
  author={Bernd Kammerer and Antje Frickenschmidt and Christa E. M{\"u}ller and Stefan Laufer and Christoph H. Gleiter and Hartmut Liebich},
  journal={Analytical and bioanalytical chemistry},
  year={2005},
  volume={382 4},
  pages={
          1017-26
        }
}
In diseases accompanied by strong metabolic disorders, like cancer and AIDS, modifying enzymes are up- or down-regulated. As a result, many different types of metabolic end-products, including abnormal amounts of modified nucleosides, are found in urine. These nucleosides are degradation products of an impaired ribonucleic acid (RNA) metabolism, which affects the nucleoside pattern in urine. In several basic experiments we elucidated the fragmentation pathways of 16 characteristic nucleosides… CONTINUE READING
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