Mass spectrometric characterization of gelsolin isoforms.

  title={Mass spectrometric characterization of gelsolin isoforms.},
  author={Gw{\"e}na{\"e}l Pottiez and Nicole A. Haverland and Pawel S Ciborowski},
  journal={Rapid communications in mass spectrometry : RCM},
  volume={24 17},
Gelsolin is the most widely expressed member of the actin capping and severing family of proteins. There are two isoforms of gelsolin: isoform 1, a secretory (plasma) protein that is 51 amino acids longer than isoform 2, a cytosolic protein, at the N-terminus; the first 27 amino acids is a signal sequence. Both isoforms are coded by a single gene and differ as a result of alternative initiation site/splicing. The level of gelsolin in the blood and cerebrospinal fluid (CSF) is altered in many… CONTINUE READING


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