Mass spectrometric amino acid sequence determination in arginine-containing peptides.

@article{Shemyakin1969MassSA,
  title={Mass spectrometric amino acid sequence determination in arginine-containing peptides.},
  author={M. M. Shemyakin and E. I. Vinogradova and Y. Ovchinnikov and A. Kiryushkin and M. Feigina and N. A. Aldanova and Y. Alakhov and V. Lipkin and B. V. Rosinov and L. Fonina},
  journal={Tetrahedron},
  year={1969},
  volume={25 24},
  pages={
          5785-806
        }
}
Abstract Methods of converting arginine residues into ornithine, N δ -pyrimidylornithine, N δ -imidazolidinonidenornithine residues in peptides have been developed. The modified peptides undergo the amino acid type of fragmentation, so that mass spectrometry can now be used for amino acid sequence determination in arginine-containing peptides. 
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References

SHOWING 1-4 OF 4 REFERENCES
Primary structure determination of peptides and proteins by mass spectrometry
A pressing problem in modern organic chemistry is the determination of the structure of polypeptides and proteins, for it is here that the needs and interests of biochemistry have far surpassedExpand