Mass spectral analysis of some derivatives and in vitro metabolites of steviol, the aglycone of the natural sweeteners, stevioside, rebaudioside A, and rubusoside.

@article{Compadre1988MassSA,
  title={Mass spectral analysis of some derivatives and in vitro metabolites of steviol, the aglycone of the natural sweeteners, stevioside, rebaudioside A, and rubusoside.},
  author={C{\'e}sar M. Compadre and Roshan A Hussain and N. P. Dhammika Nanayakkara and John M Pezzuto and A Douglas Kinghorn},
  journal={Biomedical & environmental mass spectrometry},
  year={1988},
  volume={15 4},
  pages={
          211-22
        }
}
Steviol (ent-13-hydroxykaur-16-en-19-oic acid), the aglycone of various plant-derived glycoside sweeteners consumed by human populations, is known to be mutagenic toward Salmonella tymphimurium strain TM677 when metabolically activated using a 9000 x g supernatant fraction derived from the liver of Aroclor 1254-pretreated rats. Mass spectral analysis of this diterpenoid and some analogs revealed characteristic patterns reflecting differential stereochemistry at the C/D rings and variations in… CONTINUE READING
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