Mass spectral analysis in proteomics.

  • John R. Yates
  • Published 2004 in
    Annual review of biophysics and biomolecular…


Mass spectrometry provides key tools for the analysis of proteins. New types of mass spectrometers that provide enhanced capability to discover protein identities and perform improved proteomic experiments are discussed. Handling the complex mixtures of peptides and proteins generated from protein complexes and whole cells requires multidimensional separations; several forms of separation are discussed. Applications of mass spectrometry-based approaches for contemporary proteomic analyses are described.

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@article{Yates2004MassSA, title={Mass spectral analysis in proteomics.}, author={John R. Yates}, journal={Annual review of biophysics and biomolecular structure}, year={2004}, volume={33}, pages={297-316} }