Mass defect filter technique and its applications to drug metabolite identification by high-resolution mass spectrometry.

@article{Zhang2009MassDF,
  title={Mass defect filter technique and its applications to drug metabolite identification by high-resolution mass spectrometry.},
  author={Haiying Zhang and Donglu Zhang and Kenneth L Ray and Mingshe Zhu},
  journal={Journal of mass spectrometry : JMS},
  year={2009},
  volume={44 7},
  pages={999-1016}
}
Identification of drug metabolites by liquid chromatography/mass spectrometry (LC/MS) involves metabolite detection in biological matrixes and structural characterization based on product ion spectra. Traditionally, metabolite detection is accomplished primarily on the basis of predicted molecular masses or fragmentation patterns of metabolites using triple-quadrupole and ion trap mass spectrometers. Recently, a novel mass defect filter (MDF) technique has been developed, which enables high… CONTINUE READING
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