Mass balance and metabolism of the antimalarial pyronaridine in healthy volunteers

@article{Morris2014MassBA,
  title={Mass balance and metabolism of the antimalarial pyronaridine in healthy volunteers},
  author={Carrie Ann Morris and Stephen R. Dueker and Peter Norton Lohstroh and Li-Quan Wang and Xin-Ping Fang and Donald Jung and Luis L{\'o}pez-L{\'a}zaro and Mark Baker and Stephan Duparc and Isabelle Borghini-Fuhrer and Rolf Pokorny and Jang-sik Shin and Lawrence Fleckenstein},
  journal={European Journal of Drug Metabolism and Pharmacokinetics},
  year={2014},
  volume={40},
  pages={75-86}
}
This was a single dose mass balance and metabolite characterization study of the antimalarial agent pyronaridine. Six healthy male adults were administered a single oral dose of 720 mg pyronaridine tetraphosphate with 800 nCi of radiolabeled 14C-pyronaridine. Urine and feces were continuously collected through 168 h post-dose, with intermittent 48 h collection periods thereafter through 2064 h post-dose. Drug recovery was computed for analyzed samples and interpolated for intervening time… CONTINUE READING
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