Mass and relative elution time profiling: two-dimensional analysis of sphingolipids in Alzheimer's disease brains.

@article{Hejazi2011MassAR,
  title={Mass and relative elution time profiling: two-dimensional analysis of sphingolipids in Alzheimer's disease brains.},
  author={Leila Hejazi and Jason W. H. Wong and Danni Cheng and Nicholas W Proschogo and Diako Ebrahimi and Brett Garner and Anthony S. Don},
  journal={The Biochemical journal},
  year={2011},
  volume={438 1},
  pages={165-75}
}
Current lipidomic profiling methods rely mainly on MS to identify unknown lipids within a complex sample. We describe a new approach, involving LC×MS/MS (liquid chromatography×tandem MS) analysis of sphingolipids based on both mass and hydrophobicity, and use this method to characterize the SM (sphingomyelin), ceramide and GalCer (galactosylceramide) content of hippocampus from AD (Alzheimer's disease) and control subjects. Using a mathematical relationship we exclude the influence of… CONTINUE READING

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