Mass Spectrometry of an Intact Virus.

  title={Mass Spectrometry of an Intact Virus.},
  author={Stephen D. Fuerstenau and William Henry Benner and John J. Thomas and Christophe Brugidou and Brian Bothner and Gary Siuzdak},
  journal={Angewandte Chemie},
  volume={40 3},
The simultaneous measurement of the time-of-flight and the number of charges on each electrosprayed ion provides a new way to determine the mass of a whole intact virus. The weights of an icosahedral virus (rice yellow mottle virus) consisting of a single-stranded RNA surrounded by a homogeneous protein shell with a mass of 6.5×106 Da, and a rod-shaped RNA virus (tobacco mosaic virus) with a mass of 40.5×106 Da were measured with this technique. 

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