Mass Spectrometry Screening Reveals Peptides Modulated Differentially in the Medial Prefrontal Cortex of Rats with Disparate Initial Sensitivity to Cocaine

Abstract

To better understand why certain individuals are more vulnerable to cocaine abuse and addiction, we identify peptide markers associated with individual variation in sensitivity to the behavioral effects of cocaine. Previous studies in rats show that low, compared to high, cocaine responders are more sensitive to cocaine-induced behavioral plasticity… (More)
DOI: 10.1208/s12248-010-9204-2

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@article{Romanova2010MassSS, title={Mass Spectrometry Screening Reveals Peptides Modulated Differentially in the Medial Prefrontal Cortex of Rats with Disparate Initial Sensitivity to Cocaine}, author={Elena V. Romanova and Ji Eun Lee and Neil L. Kelleher and Jonathan V. Sweedler and Joshua M Gulley}, journal={The AAPS Journal}, year={2010}, volume={12}, pages={443-454} }