Mass Spectrometry-Based Metabolomics Reveals Occupational Exposure to Per- and Polyfluoroalkyl Substances Relates to Oxidative Stress, Fatty Acid β-Oxidation Disorder, and Kidney Injury in a Manufactory in China.
@article{Lu2019MassSM, title={Mass Spectrometry-Based Metabolomics Reveals Occupational Exposure to Per- and Polyfluoroalkyl Substances Relates to Oxidative Stress, Fatty Acid $\beta$-Oxidation Disorder, and Kidney Injury in a Manufactory in China.}, author={Yao Lu and Ke Gao and Xiaona Li and Zhi Tang and Li Xiang and Hongzhi Zhao and Jianjie Fu and Ling Wang and Nali Zhu and Zongwei Cai and Yong Liang and Yawei Wang and Guibin Jiang}, journal={Environmental science \& technology}, year={2019} }
Occupational workers are usually exposed to high levels of per- and polyfluoroalkyl substances (PFASs), placing them under greater health risks compared to the general population. Herein, 40 occupational workers from a factory in China and 52 control subjects from the general population were involved in an investigation on the potential health concerns of occupational exposure to PFASs by mass spectrometry-based metabolomics analysis. The PFAS levels in plasma from both groups were analyzed…
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References
SHOWING 1-10 OF 51 REFERENCES
Serum metabolome biomarkers associate low-level environmental perfluorinated compound exposure with oxidative /nitrosative stress in humans.
- BiologyEnvironmental pollution
- 2017
Differential accumulation and elimination behavior of perfluoroalkyl Acid isomers in occupational workers in a manufactory in China.
- ChemistryEnvironmental science & technology
- 2015
In this study, serum and urine samples were collected from 36 occupational workers in a fluorochemical manufacturing plant in China from 2008 to 2012 to evaluate the body burden and possible…
Procedures for large-scale metabolic profiling of serum and plasma using gas chromatography and liquid chromatography coupled to mass spectrometry
- BiologyNature Protocols
- 2011
The experimental workflow for long-term and large-scale metabolomic studies involving thousands of human samples with data acquired for multiple analytical batches over many months and years is described.
An integrated metabonomics and transcriptomics approach to understanding metabolic pathway disturbance induced by perfluorooctanoic acid.
- BiologyJournal of pharmaceutical and biomedical analysis
- 2013
Biological Responses to Perfluorododecanoic Acid Exposure in Rat Kidneys as Determined by Integrated Proteomic and Metabonomic Studies
- BiologyPloS one
- 2011
Evidence is provided that disorders in glucose and amino acid metabolism may contribute to PFDoA nephrotoxicity and α2u globulin may play an important role in protecting the kidneys from PF doA toxicity.
Metabolomics insights into chronic kidney disease and modulatory effect of rhubarb against tubulointerstitial fibrosis
- BiologyScientific reports
- 2015
Treatment with EA, BU and PE extracts of rhubarb improved renal function and histopathological abnormalities including interstitial fibrosis and inflammation, and either fully or partially reversed the abnormalities of the urinary metabolites.
1H NMR metabolomics of Eisenia fetida responses after sub-lethal exposure to perfluorooctanoic acid and perfluorooctane sulfonate
- Biology, Environmental Science
- 2012
The data indicate that PFOA and PFOS exposure may increase fatty acid oxidation and interrupt ATP synthesis due to a disruption in the inner mitochondrial membrane structure, and NMR-based metabolomics has promise as an insightful tool for elucidating the environmental toxicology of sub-lethal contaminant exposure.
Alpha and gamma tocopherol metabolism in healthy subjects and patients with end-stage renal disease.
- Medicine, BiologyKidney international
- 2003
First, serum alpha and gamma CEHC accumulate in uremic patients compared to healthy subjects; second, supplementation with tocopherols dramatically increases serum CEHC levels in both healthy subjects and hemodialysis patients; and, finally, CEHC accumulation may mediate anti-inflammatory and antioxidative effects of tocop herols in hemodIALysis patients.
Effects of Perfluorooctanoic Acid on Metabolic Profiles in Brain and Liver of Mouse Revealed by a High-throughput Targeted Metabolomics Approach
- Biology, ChemistryScientific reports
- 2016
Inbrain and liver, profiles of lipids revealed involvement of β-oxidation and biosynthesis of saturated and unsaturated fatty acids in PFOA-induced hepatotoxicity, while alterations in metabolism of arachidonic acid suggesting potential of P FOA to cause inflammation response in liver.
Perfluorinated Chemicals as Emerging Environmental Threats to Kidney Health: A Scoping Review.
- Medicine, BiologyClinical journal of the American Society of Nephrology : CJASN
- 2018
A growing body of evidence portends PFASs are emerging environmental threats to kidney health; yet several important gaps in the understanding still exist.