Mass Cytometry and Topological Data Analysis Reveal Immune Parameters Associated with Complications after Allogeneic Stem Cell Transplantation.

@article{Lakshmikanth2017MassCA,
  title={Mass Cytometry and Topological Data Analysis Reveal Immune Parameters Associated with Complications after Allogeneic Stem Cell Transplantation.},
  author={Tadepally Lakshmikanth and Axel Olin and Yang Chen and Jaromir Mikes and Erik Fredlund and Mats Remberger and Brigitta Omazic and Petter Brodin},
  journal={Cell reports},
  year={2017},
  volume={20 9},
  pages={2238-2250}
}
Human immune systems are variable, and immune responses are often unpredictable. Systems-level analyses offer increased power to sort patients on the basis of coordinated changes across immune cells and proteins. Allogeneic stem cell transplantation is a well-established form of immunotherapy whereby a donor immune system induces a graft-versus-leukemia response. This fails when the donor immune system regenerates improperly, leaving the patient susceptible to infections and leukemia relapse… CONTINUE READING
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