Maspin suppresses survival of lung cancer cells through modulation of Akt pathway.

@article{Nam2010MaspinSS,
  title={Maspin suppresses survival of lung cancer cells through modulation of Akt pathway.},
  author={Eunsook Nam and Chaehwa Park},
  journal={Cancer research and treatment : official journal of Korean Cancer Association},
  year={2010},
  volume={42 1},
  pages={42-7}
}
PURPOSE Maspin is a tumor suppressor protein that has been reported to stimulate the cell death of cancer and inhibit the metastasis of cancer. The present study aimed to explore the survival pathway by which maspin modulates the resistance of human lung cancer cells to chemotherapeutic drugs, and the consequences of maspin gene therapy in an animal model. MATERIALS AND METHODS NCI-H157 and A549 cells were transfected with either a mock vector (pCMVTaq4C), maspin (pCMV-maspin), siControl or… CONTINUE READING