Maspin is an angiogenesis inhibitor

  title={Maspin is an angiogenesis inhibitor},
  author={Ming Zhang and Olga V. Volpert and Yihui H. Shi and No{\"e}l P. Bouck},
  journal={Nature Medicine},
Maspin, a unique member of the serpin family, is a secreted protein encoded by a class II tumor suppressor gene whose downregulation is associated with the development of breast and prostate cancers. Overexpression of maspin in breast tumor cells limits their growth and metastases in vivo. In this report we demonstrate that maspin is an effective inhibitor of angiogenesis. In vitro, it acted directly on cultured endothelial cells to stop their migration towards basic fibroblast growth factor… CONTINUE READING


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