Maspin increases Ku70 acetylation and Bax-mediated cell death in cancer cells.

@article{Lee2012MaspinIK,
  title={Maspin increases Ku70 acetylation and Bax-mediated cell death in cancer cells.},
  author={Sook-Ja Lee and Haerim Jang and Chaehwa Park},
  journal={International journal of molecular medicine},
  year={2012},
  volume={29 2},
  pages={225-30}
}
Ku70, a DNA repair protein, was recently identified as a critical anti-apoptotic protein that inhibits Bax translocation to mitochondria. The dissociation of Bax from Ku70 is essential for the apoptotic activity of Bax. Here, we show that maspin, a tumor suppressor protein frequently lost in cancer, regulates this process. Maspin increased cell death in a Ku70 acetylation-dependent manner. Maspin inhibited histone deacetylase 1 (HDAC1) and thus increased the acetylation of Ku70 and the… CONTINUE READING

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