Maslinic acid induces autophagy by down-regulating HSPA8 in pancreatic cancer cells.

@article{Tian2018MaslinicAI,
  title={Maslinic acid induces autophagy by down-regulating HSPA8 in pancreatic cancer cells.},
  author={Ye Tian and Huanli Xu and Ammad Ahmad Farooq and Baozeng Nie and Xiaoliang Chen and Shuonan Su and Ru Yuan and Gan Qiao and C Li and Xiao Li and Xiaohui Liu and Xiukun Lin},
  journal={Phytotherapy research : PTR},
  year={2018},
  volume={32 7},
  pages={
          1320-1331
        }
}
Maslinic acid (MA), a natural pentacyclictriterpene, displays cytotoxic activity on various types of cancer cells. However, its underlying mechanism is unclear. In this study, we assessed the effect of MA on autophagy of human pancreatic cancer cells, and the potential autophagic pathway was presented. MA inhibited the proliferation and induced autophagy of… CONTINUE READING