MarvelD3 couples tight junctions to the MEKK1–JNK pathway to regulate cell behavior and survival

@inproceedings{Steed2014MarvelD3CT,
  title={MarvelD3 couples tight junctions to the MEKK1–JNK pathway to regulate cell behavior and survival},
  author={Emily Steed and Ahmed Elbediwy and Barbara Vacca and S{\'e}bastien Dupasquier and Sandra A. Hemkemeyer and Tesha Suddason and Ana Catarina Costa and Jean-Bernard Beaudry and Ceniz Zihni and Ewen Gallagher and Christophe E Pierreux and Maria Susana Balda and Karl Matter},
  booktitle={The Journal of cell biology},
  year={2014}
}
MarvelD3 is a transmembrane component of tight junctions, but there is little evidence for a direct involvement in the junctional permeability barrier. Tight junctions also regulate signaling mechanisms that guide cell proliferation; however, the transmembrane components that link the junction to such signaling pathways are not well understood. In this paper, we show that MarvelD3 is a dynamic junctional regulator of the MEKK1-c-Jun NH2-terminal kinase (JNK) pathway. Loss of MarvelD3 expression… CONTINUE READING
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