Marrow transplantation for acute nonlymphocytic leukemia after treatment with busulfan and cyclophosphamide.

@article{Santos1983MarrowTF,
  title={Marrow transplantation for acute nonlymphocytic leukemia after treatment with busulfan and cyclophosphamide.},
  author={George W. Santos and Peter J. Tutschka and Ron Brookmeyer and Rein Saral and William E Beschorner and Wilma B. Bias and Hayden G. Braine and W H Burns and Gerald J. Elfenbein and Herbert Kaizer},
  journal={The New England journal of medicine},
  year={1983},
  volume={309 22},
  pages={1347-53}
}
Fifty-one patients with acute nonlymphocytic leukemia (16 with end-stage disease, 17 in second or third remission or in early relapse, and 18 in first remission) were given infusions of HLA-identical sibling marrow after cytoreduction with high doses of busulfan and cyclophosphamide. Actuarial two-year survival rates were 0 per cent, 29 per cent, and 44 per cent, respectively. Twelve patients are still alive and in remission after 327 to 1488 days, with 10 surviving beyond two years. Acute… CONTINUE READING

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