Marrow toxicity of fractionated vs. single dose total body irradiation is identical in a canine model.

@article{Storb1993MarrowTO,
  title={Marrow toxicity of fractionated vs. single dose total body irradiation is identical in a canine model.},
  author={Rainer F Storb and Robert F. Raff and Thomas Crofoot Graham and Frederick R Appelbaum and H Joachim Deeg and Friedrich G. Schuening and Howard M. Shulman and Margaret Sullivan Pepe},
  journal={International journal of radiation oncology, biology, physics},
  year={1993},
  volume={26 2},
  pages={275-83}
}
PURPOSE We explored in dogs the marrow toxicity of single dose total body irradiation delivered from two opposing 60Co sources at a rate of 10 cGy/min and compared results to those seen with total body irradiation administered in 100 cGy fractions with minimum interfraction intervals of 6 hr. Dogs were not given marrow transplants. RESULTS We found that 200 cGy single dose total body irradiation was sublethal, with 12 of 13 dogs showing hematopoietic recovery and survival. Seven of 21 dogs… CONTINUE READING