Markov models of genome segmentation.

  title={Markov models of genome segmentation.},
  author={Vivek Thakur and Rajeev K. Azad and Ram Ramaswamy},
  journal={Physical review. E, Statistical, nonlinear, and soft matter physics},
  volume={75 1 Pt 1},
We introduce Markov models for segmentation of symbolic sequences, extending a segmentation procedure based on the Jensen-Shannon divergence that has been introduced earlier. Higher-order Markov models are more sensitive to the details of local patterns and in application to genome analysis, this makes it possible to segment a sequence at positions that are biologically meaningful. We show the advantage of higher-order Markov-model-based segmentation procedures in detecting compositional… CONTINUE READING

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