Markov models of breast tumor progression: some age-specific results.

@article{Duffy1997MarkovMO,
  title={Markov models of breast tumor progression: some age-specific results.},
  author={Stephen W. Duffy and NicholasE. Day and L{\'a}szl{\'o} K. Tab{\'a}r and H. H. Chen and T C Smith},
  journal={Journal of the National Cancer Institute. Monographs},
  year={1997},
  volume={22},
  pages={
          93-7
        }
}
  • S. Duffy, N. Day, +2 authors T. Smith
  • Published 1997
  • Medicine
  • Journal of the National Cancer Institute. Monographs
Researchers have noted that mammographic screening has a reduced effect on breast cancer mortality in women in their forties compared to older women. Explanations for this include poorer sensitivity in younger women due to denser breast tissue, as well as more rapid tumor progression, giving a shorter mean sojourn time (the average duration of the preclinical screen-detectable period). To test these hypotheses, we developed a series of Markov-chain models to estimate tumor progression rates and… 
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