Markov Models for inferring copy number variations from genotype data on Illumina platforms.

  title={Markov Models for inferring copy number variations from genotype data on Illumina platforms.},
  author={Hui Wang and Jan H Veldink and Hylke Merijn Blauw and Leonard H van den Berg and Roel A. Ophoff and Chiara Sabatti},
  journal={Human heredity},
  volume={68 1},
BACKGROUND/AIMS Illumina genotyping arrays provide information on DNA copy number. Current methodology for their analysis assumes linkage equilibrium across adjacent markers. This is unrealistic, given the markers high density, and can result in reduced specificity. Another limitation of current methods is that they cannot be directly applied to the analysis of multiple samples with the goal of detecting copy number polymorphisms and their association with traits of interest. METHODS We… CONTINUE READING
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