Markers of tumor angiogenesis and proteolysis independently define high- and low-risk subsets of node-negative breast cancer patients.

@article{Eppenberger1998MarkersOT,
  title={Markers of tumor angiogenesis and proteolysis independently define high- and low-risk subsets of node-negative breast cancer patients.},
  author={Urs Eppenberger and Willy Kueng and Jean Marc Schlaeppi and Johannes L. Roesel and Christopher Benz and H Mueller and Andrea Matter and Markus Zuber and Kurt Luescher and Mario Litschgi and Manfred Schmitt and John A. Foekens and Serenella Eppenberger-Castori},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={1998},
  volume={16 9},
  pages={3129-36}
}
PURPOSE To compare the prognostic impact of tumor angiogenesis factors (vascular endothelial growth factor [VEGF], angiogenin, and basic fibroblast growth factor [bFGF]), tumor proteolysis factors (urokinase-type plasminogen activator [uPA] and plasminogen activator inhibitor-1 [PAI-1]), and conventional tumor markers (stage, grade, and steroid receptors) in early breast cancer. PATIENTS AND METHODS In the primary clinical study, tumor angiogenesis and other factors were detected in frozen… CONTINUE READING

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