Markers of nitric oxide metabolism in sputum and exhaled air are not increased in chronic obstructive pulmonary disease.

@article{Rutgers1999MarkersON,
  title={Markers of nitric oxide metabolism in sputum and exhaled air are not increased in chronic obstructive pulmonary disease.},
  author={Steven R Rutgers and Thomas W van der Mark and W Coers and Han Moshage and Wim Timens and Henk F. Kauffman and Gerard H. Ko{\"e}ter and Dirkje S Postma},
  journal={Thorax},
  year={1999},
  volume={54 7},
  pages={576-80}
}
BACKGROUND Nitric oxide (NO) is involved in inflammation and host defence of the lung. It has been found in increased concentrations in the airways in asthmatic subjects but its levels in patients with chronic obstructive pulmonary disease (COPD) have not been investigated. A study was undertaken to determine whether markers of NO metabolism (NO in exhaled air, iNOS expression in sputum cells, and nitrite + nitrate (NO2-/NO3-) in sputum supernatant) are increased in subjects with COPD, and… CONTINUE READING
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