Markers of immune stimulation in the cerebrospinal fluid during HIV infection: a longitudinal study.

@article{Gissln1994MarkersOI,
  title={Markers of immune stimulation in the cerebrospinal fluid during HIV infection: a longitudinal study.},
  author={Magnus Gissl{\'e}n and F Chiodi and Dietmar Fuchs and Gunnar Norkrans and Bo Svennerholm and Helmut Wachter and Lars Axel Hagberg},
  journal={Scandinavian journal of infectious diseases},
  year={1994},
  volume={26 5},
  pages={523-33}
}
Markers of immune stimulation were studied in 76 sequential cerebrospinal fluid (CSF) samples from 19 patients infected with HIV-1 without antiretroviral treatment during observation periods ranging from 22 months to 6 years. Eight of these patients were further followed with 14 CSF samples for 3-24 months of zidovudine treatment. During the course of HIV-1 infection, the mean CSF neopterin and beta 2-microglobulin (beta 2M) concentrations increased from 12.7 to 20.4 nmol/l (p < 0.01) and from… CONTINUE READING

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