Markers of immune activation and viral load in HIV-associated sensory neuropathy.

  title={Markers of immune activation and viral load in HIV-associated sensory neuropathy.},
  author={Giovanni Schifitto and Michael P Mcdermott and Justin C. Mcarthur and Karen S. Marder and Ned Sacktor and Daniel R. McClernon and Kathy Conant and Bruce Cohen and Leon G. Epstein and Karl K Kieburtz},
  volume={64 5},
BACKGROUND HIV infection is associated with a painful distal sensory polyneuropathy (DSP) that can severely limit the quality of life of affected subjects. The pathogenesis of DSP is unknown, although both HIV proteins and products of immune activation triggered by HIV infection have been implicated. OBJECTIVE To assess the association between baseline markers of immune activation and HIV RNA levels (viral load) and time to symptomatic DSP (SDSP). METHODS A cohort of 376 subjects, most… CONTINUE READING
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