Markers of eosinophilic inflammation for diagnosis of eosinophilic esophagitis and proton pump inhibitor-responsive esophageal eosinophilia: a prospective study.

@article{Dellon2014MarkersOE,
  title={Markers of eosinophilic inflammation for diagnosis of eosinophilic esophagitis and proton pump inhibitor-responsive esophageal eosinophilia: a prospective study.},
  author={Evan S. Dellon and Olga Speck and Kimberly R Woodward and Shannon Covey and Spencer Rusin and Jessica H. Gebhart and Xiaoxin Chen and John T. Woosley and N J Shaheen},
  journal={Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association},
  year={2014},
  volume={12 12},
  pages={2015-22}
}
BACKGROUND & AIMS Distinguishing between eosinophilic esophagitis (EoE), gastroesophageal reflux disease, and proton pump inhibitor-responsive esophageal eosinophilia (PPI-REE) is challenging. We assessed whether immunohistochemical analysis of esophageal tissues for major basic protein (MBP), eotaxin-3, and tryptase can be used for diagnosis of EoE and to differentiate EoE from PPI-REE. METHODS We conducted a prospective study of 196 consecutive adults who underwent outpatient endoscopy at… CONTINUE READING
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