Markers of endothelial dysfunction differ between subphenotypes in children with sickle cell disease.

@article{Land2013MarkersOE,
  title={Markers of endothelial dysfunction differ between subphenotypes in children with sickle cell disease.},
  author={V van der Land and Marjolein Peters and Bart J. Biemond and Harri{\"e}t Heijboer and Cornelis L. Harteveld and Karin Fijnvandraat},
  journal={Thrombosis research},
  year={2013},
  volume={132 6},
  pages={712-7}
}
In adult patients with sickle cell disease two distinct subphenotypes have previously been defined: patients with the viscosity-vaso-occlusion subphenotype (VVO) suffer mainly from vaso-occlusive pain crises and have a relatively high hemoglobin concentration. Patients classified as the hemolysis-endothelial dysfunction subphenotype (HED) suffer from stroke and pulmonary hypertension and have an elevated concentration of lactate dehydrogenase. However, this classification is not possible in… CONTINUE READING