Markers of electrophilic stress caused by chemically reactive metabolites in human hepatocytes.

@article{Takakusa2008MarkersOE,
  title={Markers of electrophilic stress caused by chemically reactive metabolites in human hepatocytes.},
  author={Hideo Takakusa and Hiroshi Masumoto and Ayako Mitsuru and Osamu Tatsuma Okazaki and Kenichi Sudo},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2008},
  volume={36 5},
  pages={816-23}
}
The metabolic activation of a drug to an electrophilic reactive metabolite and its covalent binding to cellular macromolecules is considered to be involved in the occurrence of idiosyncratic drug toxicity (IDT). As a cellular defense system against oxidative and electrophilic stress, phase II enzymes are known to be induced through a Kelch-like ECH-associated protein 1/nuclear factor E2-related factor 2/antioxidant response element system. We presumed that it is important for the risk… CONTINUE READING
17 Extracted Citations
32 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 17 extracted citations

Referenced Papers

Publications referenced by this paper.
Showing 1-10 of 32 references

Similar Papers

Loading similar papers…