Markers of degeneration and regeneration in Duchenne muscular dystrophy.

  title={Markers of degeneration and regeneration in Duchenne muscular dystrophy.},
  author={Eglal Abdel-Salam and I. E. Abdel-Meguid and Soheir Korraa},
  journal={Acta myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of Myology},
  volume={28 3},
Dystrophin deficiency associated with Duchenne muscular dystrophy (DMD) results in chronic inflammation and severe skeletal muscle degeneration, where the extent of muscle fibrosis contributes to disease severity. The microenvironment of dystrophic muscles is associated with variation in levels of markers of degeneration and regeneration. Since in dystrophic muscle apoptosis precedes necrosis, markers of apoptosis can be used as indicators of degeneration, while regeneration can be measured in… CONTINUE READING
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