Markers of cell proliferation in normal epithelia and dysplastic leukoplakias of the oral cavity.

  title={Markers of cell proliferation in normal epithelia and dysplastic leukoplakias of the oral cavity.},
  author={S C Liu and Edward R Sauter and Margie Lee Clapper and Roy S. Feldman and Linda Levin and Si Yi Chen and Timothy J. Yen and Ed Ross and Paul F. Engstrom and Andres J. P. Klein-Szanto},
  journal={Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology},
  volume={7 7},
The expression of several markers of epithelial cell proliferation was analyzed to establish baseline data for future chemoprevention studies of oral premalignant lesions. Punch biopsies (n = 60) from three different sites of oral mucosa (bucca, lateral tongue, and the floor of the mouth) were obtained from 20 normal donors of both sexes. After formaldehyde fixation and paraffin embedding, immunohistochemistry was used to detect the proliferation markers Mib-1, cyclin D1, and centromere… CONTINUE READING


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