Markers of Tumor-Initiating Cells Predict Chemoresistance in Breast Cancer

@inproceedings{Gong2010MarkersOT,
  title={Markers of Tumor-Initiating Cells Predict Chemoresistance in Breast Cancer},
  author={Chang Gong and H R Yao and Qiang Liu and Jingqi Chen and Junwei Shi and Fengxi Su and Erwei Song},
  booktitle={PloS one},
  year={2010}
}
PURPOSE Evidence is lacking whether the number of breast tumor-initiating cells (BT-ICs) directly correlates with the sensitivity of breast tumors to chemotherapy. Here, we evaluated the association between proportion of BT-ICs and chemoresistance of the tumors. METHODS Immunohistochemical staining(IHC) was used to examine the expression of aldehyde dehydrogenase 1 (ALDH1) and proliferating cell nuclear antigen, and TUNEL was used to detect the apoptosis index. The significance of various… CONTINUE READING

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by high - throughput screening

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