Markers of Inflammation and Oxidative Stress in the Development and Progression of Renal Disease in Diabetic Patients

@article{Hojs2016MarkersOI,
  title={Markers of Inflammation and Oxidative Stress in the Development and Progression of Renal Disease in Diabetic Patients},
  author={Radovan Hojs and Robert Ekart and Sebastjan Bevc and Nina Hojs},
  journal={Nephron},
  year={2016},
  volume={133},
  pages={159 - 162}
}
The prevalence of diabetes is increasing and has already reached pandemic proportions. Diabetes is a well-known risk factor for chronic kidney disease. Diabetic kidney disease (DKD) occurs in up to 40% of people with type 1 or 2 diabetes and is nowadays the leading cause of end-stage renal disease (ESRD). Among several factors involved in the development and progression of DKD are also inflammation and oxidative stress. Unfortunately, there is a paucity of sensitive and specific biomarkers for… Expand
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Inflammatory Targets in Diabetic Nephropathy
TLDR
This review focuses on the pathogenesis of proinflammatory molecules and mechanisms related to the development and progression of DN, and discusses the potential utility of new strategies based on agents that target inflammation. Expand
Inflammation in Diabetic Kidney Disease
TLDR
This new pathogenic perspective of DKD as an inflammatory condition leads to novel horizons, such as the potential role of inflammatory signaling pathways and their downstream products as emerging biomarkers and promising therapeutic targets. Expand
Review on Inflammation Markers in Chronic Kidney Disease
TLDR
Evidence on markers of inflammation and their role in the development and progression of CKD will focus primarily on cytokines, chemokines, and cell adhesion molecules. Expand
Evaluation of Glycemic, Lipid, Immune-Inflammatory and Oxidative Stress Markers in Various Clinical Stages of Type 2 Diabetic Nephropathy
TLDR
A significant positive correlation was found between PLBS, LDL-C and CRP and oxidative stress markers (MDA, NO, DNA damage) suggesting that monitoring these biochemical parameters at regular intervals may reduce the stage wise progression of type 2 DN and might help in early detection, precise prognosis/therapeutic modalities. Expand
Effects of metabolic memory on inflammation and fibrosis associated with diabetic kidney disease: an epigenetic perspective
  • Wen Zheng, Jia Guo, Zhangzuo Liu
  • Medicine
  • Clinical epigenetics
  • 2021
TLDR
The latest epigenetic mechanisms involved in the renal pathology of both type 1 (T1DN) and type 2 diabetic nephropathy (T2DN) are reviewed and the emerging role and possible therapeutic strategies based on the understanding of the role of epigenetics in DKD-associated inflammation and fibrogenesis are highlighted. Expand
Renal expression of cytokines and chemokines in diabetic nephropathy
TLDR
It was observed that eotaxin may have an important role in the progression of interstitial inflammation in DN and in eGFR decrease of these patients, and an increased in situ production of cytokines and chemokines in DN. Expand
Type 2 diabetes mellitus, oxidative stress and inflammation: examining the links.
  • O. Oguntibeju
  • Medicine
  • International journal of physiology, pathophysiology and pharmacology
  • 2019
TLDR
The interaction between diabetes, oxidative stress and inflammation, factors promoting prevalence of diabetes mellitus, mechanisms involved in hyperglycaemia-induced oxidative stress with particular focus on type 2 diabetes and selected diabetic complications are examined. Expand
Unraveling the Role of Inflammation in the Pathogenesis of Diabetic Kidney Disease
TLDR
This review provides an overview of the current status of knowledge regarding the pathologic roles of inflammation in the development of DKD and summarizes recent therapeutic advances to prevent DKD, with a focus on the anti-inflammatory effects of newly developed agents. Expand
The Efficacy and Mechanism of Chinese Herbal Medicine on Diabetic Kidney Disease
TLDR
The progress of Chinese herbal medicine (CHM) in the treatment of DKD is summarized from two aspects: in clinical trials, the Chinese herbal formulas were efficacy and safety confirmed by the randomized controlled trials, and in experimental research, studies provided evidence for the efficacy of CHM. Expand
THE ROLE OF OXIDATIVE STRESS AND MICROALBUMINURIA THE EARLIEST MARKER OF DIABETIC NEPHROPATHY
Aim &Objectives: To study the role of oxidative stress causing nephropathy in diabetes mellitus. The earliest indication of nephropathy is microalbuminuria. Materials & Methods: The study included 25… Expand
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