Markers of Endogenous Desaturase Activity and Risk of Coronary Heart Disease in the CAREMA Cohort Study

@inproceedings{Lu2012MarkersOE,
  title={Markers of Endogenous Desaturase Activity and Risk of Coronary Heart Disease in the CAREMA Cohort Study},
  author={Yingchang Tang Lu and Anika A. M. Vaarhorst and Audrey H. H. Merry and Martijn E. T. Doll{\'e} and Robert Hovenier and Sandra Imholz and Leo J Schouten and Bastiaan T Heijmans and Michael M{\"u}ller and Pieternella E Slagboom and Piet A van den Brandt and Anton P. M. Gorgels and Jolanda M. A. Boer and Edith J. M. Feskens},
  booktitle={PloS one},
  year={2012}
}
BACKGROUND Intakes of n-3 polyunsaturated fatty acids (PUFAs), especially EPA (C20:5n-3) and DHA (C22:6n-3), are known to prevent fatal coronary heart disease (CHD). The effects of n-6 PUFAs including arachidonic acid (C20:4n-6), however, remain unclear. δ-5 and δ-6 desaturases are rate-limiting enzymes for synthesizing long-chain n-3 and n-6 PUFAs. C20:4n-6 to C20:3n-6 and C18:3n-6 to C18:2n-6 ratios are markers of endogenous δ-5 and δ-6 desaturase activities, but have never been studied in… CONTINUE READING

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