Markers of Electrophilic Stress Caused by Chemically Reactive Metabolites in Human Hepatocytes

  title={Markers of Electrophilic Stress Caused by Chemically Reactive Metabolites in Human Hepatocytes},
  author={H. Takakusa and H. Masumoto and A. Mitsuru and O. Okazaki and K. Sudo},
  journal={Drug Metabolism and Disposition},
  pages={816 - 823}
  • H. Takakusa, H. Masumoto, +2 authors K. Sudo
  • Published 2008
  • Medicine, Chemistry
  • Drug Metabolism and Disposition
  • The metabolic activation of a drug to an electrophilic reactive metabolite and its covalent binding to cellular macromolecules is considered to be involved in the occurrence of idiosyncratic drug toxicity (IDT). As a cellular defense system against oxidative and electrophilic stress, phase II enzymes are known to be induced through a Kelch-like ECH-associated protein 1/nuclear factor E2-related factor 2/antioxidant response element system. We presumed that it is important for the risk… CONTINUE READING
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