Markers and function of human NK cells in normal and pathological conditions.

@article{Zotto2017MarkersAF,
  title={Markers and function of human NK cells in normal and pathological conditions.},
  author={Genny del Zotto and Emanuela Marcenaro and Paola Vacca and Simona Sivori and Daniela Pende and Mariella Della Chiesa and Francesca Della Moretta and Tiziano Ingegnere and Maria Cristina Mingari and Alessandro Moretta},
  journal={Cytometry. Part B, Clinical cytometry},
  year={2017},
  volume={92 2},
  pages={100-114}
}
Natural killer (NK) cells, the most important effectors of the innate lymphoid cells (ILCs), play a fundamental role in tumor immune-surveillance, defense against viruses and, in general, in innate immune responses. NK cell activation is mediated by several activating receptors and co-receptors able to recognize ligands on virus-infected or tumor cells. To prevent healthy cells from auto-aggression, NK cells are provided with strong inhibitory receptors (KIRs and NKG2A) which recognize HLA… CONTINUE READING