Marker profiling of normal keratinocytes identifies the stroma from squamous cell carcinoma of the oral cavity as a modulatory microenvironment in co-culture.

@article{Lacina2007MarkerPO,
  title={Marker profiling of normal keratinocytes identifies the stroma from squamous cell carcinoma of the oral cavity as a modulatory microenvironment in co-culture.},
  author={Luk{\'a}{\vs} Lacina and Barbora Dvoř{\'a}nkov{\'a} and Karel Smetana and Martin Chovanec and Jan Plz{\'a}k and Ruth Tachezy and Linda Kideryov{\'a} and Lucia Kucerova and Zdeněk {\vC}ada and Jan Bou{\vc}ek and R. Kodet and Sabine Andr{\'e} and Hans-Joachim Gabius},
  journal={International journal of radiation biology},
  year={2007},
  volume={83 11-12},
  pages={837-48}
}
PURPOSE The microenvironment established by stromal cells may or may not influence phenotypic aspects of epithelial cells and may be relevant for tumor and stem cell biology. We address this issue for keratinocytes using tumor-derived stromal cells in a co-culture system. MATERIALS AND METHODS We isolated stromal cells from human squamous cell carcinoma tissue and studied their effect on phenotypic characteristics of normal human interfollicular keratinocytes in vitro. RESULTS Stromal… CONTINUE READING