Marker genes for circulating tumour cells predict survival in metastasized breast cancer patients

@article{Weigelt2003MarkerGF,
  title={Marker genes for circulating tumour cells predict survival in metastasized breast cancer patients},
  author={Britta Weigelt and Astrid Bosma and Augustinus A. M. Hart and Sjoerd Rodenhuis and L J van 't Veer},
  journal={British Journal of Cancer},
  year={2003},
  volume={88},
  pages={1091 - 1094}
}
We investigated the prognostic significance of circulating breast cancer cells in peripheral blood detected by quantitative RT–PCR of marker genes in patients with advanced breast cancer. Blood samples from 94 breast cancer patients with metastatic disease (M1) were examined for circulating tumour cells by studying the mRNA expression of CK19, p1B, PS2 and EGP2 by real-time PCR. Using a score function, developed for predicting circulating tumour cells by quadratic discriminant analysis (QDA… CONTINUE READING
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The detection of minimal numbers of contaminating epithelial tumor cells in blood or bone marrow: use, limitations and future of RNA-based methods

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