Marker chromosomes: cytogenetic characterization and implications for prenatal diagnosis.

@article{Mohandas1985MarkerCC,
  title={Marker chromosomes: cytogenetic characterization and implications for prenatal diagnosis.},
  author={Thuluvancheri Mohandas and N. Canning and W Chu and Merry B. Passage and Carol E. Anderson and Michael M. Kaback},
  journal={American journal of medical genetics},
  year={1985},
  volume={20 2},
  pages={361-8}
}
Satellited marker chromosomes were identified in four individuals from unrelated families; one was first encountered in cultured amniotic fluid cells obtained for prenatal diagnostic studies. We present cytogenetic characterization of these marker chromosomes and clinical findings in the individuals carrying them. Identification of a marker chromosome in amniotic fluid cell cultures presents problems in genetic counseling, as it is often difficult to determine the clinical significance of such… CONTINUE READING