Markedly reduced severity of Dengue virus infection in mosquito cell cultures persistently infected with Aedes albopictus densovirus (AalDNV).

@article{Burivong2004MarkedlyRS,
  title={Markedly reduced severity of Dengue virus infection in mosquito cell cultures persistently infected with Aedes albopictus densovirus (AalDNV).},
  author={Peangpim Burivong and Sa-nga Pattanakitsakul and Supatra Thongrungkiat and Prida Malasit and Timothy William Flegel},
  journal={Virology},
  year={2004},
  volume={329 2},
  pages={261-9}
}
AalDNV-infected C6/36 cells serially passaged for over 10 weeks showed a decline in percentage of anti-AalDNV-positive cells (APC) from an initial 92% to approximately 20%. Cultures of persistent APC were indistinguishable from uninfected cultures by direct microscopy but most stained cells from early APC passages had enlarged nuclei with eosinophilic inclusions, while late APC passages had few and naive cells none. Super challenge of persistent APC cultures did not increase percentage APC and… CONTINUE READING

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