Markedly increased circulating pyridoxal-5'-phosphate levels in hypophosphatasia. Alkaline phosphatase acts in vitamin B6 metabolism.

@article{Whyte1985MarkedlyIC,
  title={Markedly increased circulating pyridoxal-5'-phosphate levels in hypophosphatasia. Alkaline phosphatase acts in vitamin B6 metabolism.},
  author={Michael P Whyte and J. Dennis Mahuren and Lauri A. Vrabel and Stephen P. Coburn},
  journal={The Journal of clinical investigation},
  year={1985},
  volume={76 2},
  pages={752-6}
}
Markedly increased circulating concentrations of pyridoxal-5'-phosphate (PLP) were found in each of 14 patients representing all clinical forms of hypophosphatasia, an inborn error characterized by deficient activity of the tissue nonspecific (bone/liver/kidney) isoenzyme of alkaline phosphatase (AP). The mean PLP concentration in plasma was 1174 nM (range… CONTINUE READING