Markedly decreased expression of glutathione S-transferase pi gene in human cancer cell lines resistant to buthionine sulfoximine, an inhibitor of cellular glutathione synthesis.

@article{Yokomizo1995MarkedlyDE,
  title={Markedly decreased expression of glutathione S-transferase pi gene in human cancer cell lines resistant to buthionine sulfoximine, an inhibitor of cellular glutathione synthesis.},
  author={Akira Yokomizo and Kimitoshi Kohno and Mikio Wada and Misaki Ono and Charles S. Morrow and Kenneth H. Cowan and Michihiko Kuwano},
  journal={The Journal of biological chemistry},
  year={1995},
  volume={270 33},
  pages={19451-7}
}
Buthionine sulfoximine (BSO) is a synthetic amino acid that irreversibly inhibits an enzyme, gamma-glutamylcysteine synthetase (gamma-GCS), which is a critical step in glutathione biosynthesis. We isolated three BSO-resistant sublines, KB/BSO1, KB/BSO2, and KB/BSO3, from human epidermoid cancer KB cells. These cell lines showed 10-to 13-fold higher resistance to BSO, respectively, and had collateral sensitivity to cisplatin, ethacrynic acid, and alkylating agents such as melphalan and… CONTINUE READING

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