Marked variability of melphalan plasma drug levels during regional hyperthermic isolated limb perfusion.

@article{Cheng2003MarkedVO,
  title={Marked variability of melphalan plasma drug levels during regional hyperthermic isolated limb perfusion.},
  author={Tsung-Yen Cheng and Elizabeth K. Grubbs and Omar Abdul-Wahab and Szu-yun Leu and Chen-Fang Hung and William Petros and Thomas A. Aloia and Randy Fedrau and Scott K. Pruitt and M. James Colvin and Henry B. Friedman and Douglas M Tyler},
  journal={American journal of surgery},
  year={2003},
  volume={186 5},
  pages={
          460-7
        }
}
BACKGROUND Hyperthermic isolated limb perfusion (HILP) with melphalan as treatment for locally recurrent or in-transit malignant melanoma is frequently performed but the principle for calculating drug dosage remains poorly understood. METHODS This study examined the pharmacokinetic profile of 14 consecutive patients to determine what variables were associated with toxicity and tumor responses. RESULTS Marked fourfold variability was noted in patient plasma melphalan concentrations. We… CONTINUE READING
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