Marked regional differences of brain human apolipoprotein E expression in targeted replacement mice.

@article{Sullivan2004MarkedRD,
  title={Marked regional differences of brain human apolipoprotein E expression in targeted replacement mice.},
  author={Patrick M Sullivan and Brian E. Mace and Nobuaki Maeda and Donald E. Schmechel},
  journal={Neuroscience},
  year={2004},
  volume={124 4},
  pages={725-33}
}
We used three human apolipoprotein (apo) E targeted replacement mouse lines, each expressing one of the three common human apoE isoforms to study the pattern of apoE expression in the central nervous system (CNS). Immunocytochemistry on brain sections from all three lines of targeted replacement mice, wild type mice, African green monkeys, and humans show a predominantly glial pattern of apoE expression. The levels of human apoE protein in hippocampus and frontal cortex were similar between… CONTINUE READING