Marked reduction in gonadal steroid hormone levels in rats treated neonatally with monosodium L-glutamate: further evidence for disruption of hypothalamic-pituitary-gonadal axis regulation.

@article{Nemeroff1981MarkedRI,
  title={Marked reduction in gonadal steroid hormone levels in rats treated neonatally with monosodium L-glutamate: further evidence for disruption of hypothalamic-pituitary-gonadal axis regulation.},
  author={Charles B. Nemeroff and Coral A. Lamartiniere and George A. Mason and Randal Squibb and Jau Shong Hong and Stephen C Bondy},
  journal={Neuroendocrinology},
  year={1981},
  volume={33 5},
  pages={265-7}
}
Serum levels of luteinizing hormone (LH), follicle stimulating hormone (FSH), prolactin, estradiol-17 beta and testosterone were determined in adult rats that were treated in the neonatal period with monosodium L-glutamate (MSG) which has previously been shown to reliably produce destruction of arcuate nucleus perikarya. MSG-treated males had significantly smaller accessory sexual organs (seminal vesicles and ventral prostate) and tests and had significantly lower serum concentrations of FSH… CONTINUE READING
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