Marked recovery of severe renal lesions in POEMS syndrome with high-dose melphalan therapy supported by autologous blood stem cell transplantation.

@article{Sanada2006MarkedRO,
  title={Marked recovery of severe renal lesions in POEMS syndrome with high-dose melphalan therapy supported by autologous blood stem cell transplantation.},
  author={Satoru Sanada and Susumu Ookawara and Hiroki Karube and Tetsuro Shindo and Toshikazu Goto and Takashi Nakamichi and Mikio Saito and Mitsunobu Matsubara and Masayuki Suzuki},
  journal={American journal of kidney diseases : the official journal of the National Kidney Foundation},
  year={2006},
  volume={47 4},
  pages={672-9}
}
POEMS syndrome is a rare plasma cell disorder, characterized by polyneuropathy, organomegaly, endocrinopathy, serum monoclonal protein, and skin lesions. Although not included in the acronym, renal lesions also are characteristic of this disease and sometimes require dialysis therapy. We treated a 61-year-old woman with POEMS syndrome with high-dose melphalan therapy (HDT) supported by autologous blood stem cell transplantation (SCT), and clinical remission was achieved. A repeated renal biopsy… CONTINUE READING
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