Marked prolongation of cardiac allograft survival by dendritic cells genetically engineered with NF-kappa B oligodeoxyribonucleotide decoys and adenoviral vectors encoding CTLA4-Ig.

@article{Bonham2002MarkedPO,
  title={Marked prolongation of cardiac allograft survival by dendritic cells genetically engineered with NF-kappa B oligodeoxyribonucleotide decoys and adenoviral vectors encoding CTLA4-Ig.},
  author={Catherine A Bonham and Lansha Peng and Xiaoyan Liang and Zongyou Chen and Lianfu Wang and Linlin Ma and H Hackstein and P. David Robbins and Angus W Thomson and John J. Fung and Shiguang Qian and Li-na Lu},
  journal={Journal of immunology},
  year={2002},
  volume={169 6},
  pages={3382-91}
}
Bone marrow-derived dendritic cells (DCs) can be genetically engineered using adenoviral (Ad) vectors to express immunosuppressive molecules that promote T cell unresponsiveness. The success of these DCs for therapy of allograft rejection has been limited in part by the potential of the adenovirus to promote DC maturation and the inherent ability of the DC to undergo maturation following in vivo administration. DC maturation occurs via NF-kappaB-dependent mechanisms, which can be blocked by… CONTINUE READING

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