Marked prevention of tumor growth and metastasis by a novel immunosuppressive agent, FTY720, in mouse breast cancer models.

@article{Azuma2002MarkedPO,
  title={Marked prevention of tumor growth and metastasis by a novel immunosuppressive agent, FTY720, in mouse breast cancer models.},
  author={Haruhito Azuma and Shizuko Takahara and Naotsugu Ichimaru and Jing Wang and Ikuo Momohara and Yoshinori Otsuki and Junji Morimoto and Ryosuke Fukui and Masaaki Hoshiga and Tadashi Ishihara and Norio Nonomura and Seiichi Chiyoda-ku Suzuki and Akihiko Okuyama and Yoji Katsuoka},
  journal={Cancer research},
  year={2002},
  volume={62 5},
  pages={
          1410-9
        }
}
FTY720 is a unique immunosuppressive agent that exerts its activity by inducing apoptosis in lymphocytes. We conducted the present study to investigate the effects of FTY720 on cancer growth and metastasis, as well as its mechanism of action. In vitro treatment with FTY720 induced dramatic cancer cell apoptosis in a mouse breast cancer cell line, JygMC(A). Electron microscopy revealed distinct changes on the cell surface with decreased filopodias and microvilli in cancer cells treated with… CONTINUE READING

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