Marked platelet activation in vivo after intravenous streptokinase in patients with acute myocardial infarction.

  title={Marked platelet activation in vivo after intravenous streptokinase in patients with acute myocardial infarction.},
  author={Desmond J. Fitzgerald and F Catella and Louis Roy and Garret A. FitzGerald},
  volume={77 1},
We assessed thromboxane biosynthesis as an index of platelet activation in 6 patients with acute myocardial infarction receiving intravenous streptokinase. Urinary 2,3-dinor-thromboxane B2 and plasma 11-dehydro-thromboxane B2, major enzymatic metabolites of thromboxane A2, were markedly increased after intravenous streptokinase (11,063 +/- 2758 pg/mg creatinine and 33 +/- 10 pg/ml, respectively) compared with levels in patients not receiving thrombolytic therapy (502 +/- 89 pg/mg creatinine and… CONTINUE READING
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Randomized trial of intravenous recombinant tissue-type plasminogen activator versus intravenous streptokinase in acute myocardial infarction

  • HR Michels, W Rutsch, M Schartl, W Schmidt, R Uebis, R von Essen
  • Vol. 77,
  • 1988

Is vasospasm related to platelet deposition ? In vivo relationship in a pig model of arterial injury

  • Lam JYT, JH Cheseboro, PM Steele, V Fuster
  • Circulation
  • 1987

Platelet dependent reocclusion following coronary thrombolysis with tissue plasminogen activator

  • DJ Fitzgerald, F Wright, GA FitzGerald
  • Clin Res
  • 1987

1 1dehydro thromboxane B 2 : A quantitative index of thromboxane A 2 formation in the human circualation

  • GA FitzGerald, AK Pedersen, C Patrono
  • Proc Natl Acad Sci USA
  • 1986

A monoclonal antiplatelet antibody prevents acute coronary reocclusion ( RO ) following thrombolysis in dogs despite residual high - grade stenosis

  • DJ Fitzgerald, L Roy, F Catella, GA FitzGerald
  • Clin Res
  • 1986

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