Marked platelet activation in vivo after intravenous streptokinase in patients with acute myocardial infarction.

@article{Fitzgerald1988MarkedPA,
  title={Marked platelet activation in vivo after intravenous streptokinase in patients with acute myocardial infarction.},
  author={Desmond J. Fitzgerald and F Catella and Louis Roy and Garret A. FitzGerald},
  journal={Circulation},
  year={1988},
  volume={77 1},
  pages={142-50}
}
We assessed thromboxane biosynthesis as an index of platelet activation in 6 patients with acute myocardial infarction receiving intravenous streptokinase. Urinary 2,3-dinor-thromboxane B2 and plasma 11-dehydro-thromboxane B2, major enzymatic metabolites of thromboxane A2, were markedly increased after intravenous streptokinase (11,063 +/- 2758 pg/mg creatinine and 33 +/- 10 pg/ml, respectively) compared with levels in patients not receiving thrombolytic therapy (502 +/- 89 pg/mg creatinine and… CONTINUE READING
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Randomized trial of intravenous recombinant tissue-type plasminogen activator versus intravenous streptokinase in acute myocardial infarction

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Is vasospasm related to platelet deposition ? In vivo relationship in a pig model of arterial injury

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